Is this another alternate reality storyline like Centennial Charmed? (If you know you know.)

The power of two are coming to Grey’s Anatomy.

Former Charmed stars, icons and legends Alyssa Milano and Holly Marie Combs are reuniting on-screen for the first time since the show’s conclusion on the long-running medical drama – and once again, they’re playing sisters!

They will play the sisters of a patient who becomes braindead after an accident at a construction site; unfortunately, Leo won’t be on standby to heal their sibling, so they’ll have to decide if they want to keep her on life support.

The stars reunited with Charmed’s former executive producers Krista Vernoff and Andy Reaser on the series. They will make their Grey’s Anatomy on the third episode of the show’s upcoming 16th season, which will air 10 October.

“This is going to be fun!” said Milano while Combs tweeted: “#castfromthepast with all the feels and I mean ALLLL.”

Airing for eight seasons, Charmed focused on the most powerful witches in the world who use their combined “Power of Three” to vanquish demons, warlocks, all evil-dwellers, etc, all while maintaining their personal and professional lives.

Milano and Combs starred as Phoebe and Piper Halliwell for its entire run.

It also starred Shannen Doherty as Prue Halliwell, the third and oldest sister who was controversially killed in the season three finale. She was replaced with Rose McGowan’s character Paige Matthews, who later completed the Power of Three.

At 178 episodes, the show became the longest running hour-long television series featuring all female leads (until it was surpassed by Desperate Housewives in 2012) and the second-longest drama broadcast by The WB network.

The show developed a cult following, and is often described by critics as one of the most influential television shows of all time.

Because of its critical acclaim (and because it was the second most streamed show of 2012, six years after the finale), Charmed received a reboot by The CW, which aired its first episode on 14 October 2018.

Related: The 15 best episodes of Charmed ranked.